Synthesis Of Aspirin Synthesis - 825 Words

Synthesis of Aspirin Erin Chase Arellano CHEM 12A ABSTRACT Acetylsalicylic or most commonly known as Aspirin is made through a combination of salicylic acid and acetic anhydride. It is use to relieve mild to moderate pain such as muscle pain, headaches and common cold and reduce fever. The objective of this experiment was to synthesize aspirin from salicylic acid and acetic anhydride. The purity of aspirin was tested using the ferric chloride test and % yield was also calculated. Below drawing is the synthesis reaction of aspirin: PROCEDURE Preparations of Acetylsalicylic Acid (Aspirin) Prepare a hot water bath using a 250 ml beaker and a hot plate. Add 100 ml of water into a beaker. Adjust the temperature of the hot plate to 50 C.†¦show more content†¦Stir them and note the color change. DATA Mass, Volumes and yields Mass of Salicylic acid (g) 0.211 g Volume of acetic anhydride(ml): 0.479 ml Mass of Aspirin product (g) 0. 173 g Percent yield 63.1% Percent Recovery 82% Melting Point Softening point ( ° C) 128.1 Melting point ( ° C) 131.9 Melting point error 2.30 % Ferric Chloride Test Result Test Tube #1 (Salicylic acid) Dark Purple Test Tube #2 (Aspirin product) Pale Purple Test Tube #3 (None) None CALCULATIONS Theoretical Yield 0.210g Ãâ€"(1 mol Salicylic Acid)/(138.12 g Salicylic Acid) Ãâ€"(1 mol Aspirin)/(1 mol Salicylic Acid) (180.16 g Aspirin)/(1 mol Aspirin ) =0.274 g Aspirin Percent Yield (Actual Yield)/(Theoretical Yield) Ãâ€"100= (0.173 g)/(0.274 g) Ãâ€"100=63.1% Percent Recovery (0.173 g)/0.211g x 100=82% Percent error of melting point (135- 131.9)/135 x 100=2.30 % DISCUSSION AND CONCLUSIONS In this experiment, the actual yield of the aspirin synthesized was 0.173 g and a theoretical yield of 0.274 g. As a result, there was a 36.9% error with a reasonable percent yield of 63.1 %. Several factors can cause product loss on this experiment. One of them was transferring the product to another flask. The product may not have been fully transferred and still have remaining residue. Another example of this was during the vacuum filtration process, I have noticed that theShow MoreRelatedSynthesis of Aspirin1618 Words   |  7 Pagesobjective was to convert a specific amount of salicylic acid into the same amount of aspirin that was high in purity. Furthermore, the other objectives were to enable students to conduct the synthesis of aspirin, reinforce skills or recrystallisation and the technique of melting point determination. The amount of each compound should be the same because there is a 1:1 ratio between them. The purity of the synthesized aspi rin was measured by determining its melting point and percent yield. Soluble impuritiesRead MoreExperiment : Synthesis Of Aspirin1147 Words   |  5 PagesOctober 6th, 2014 Experiment 5: Synthesis of Aspirin Abstract: In today’s experiment, aspirin was synthesized using salicylic acid, acetic anhydride, a catalyst (concentrated sulfuric acid), and water. The main goal of this experiment was to synthesize pure aspirin. Another goal was to test aspirin’s purity by running a TLC and getting a melting point test done. Also, calculations of the theoretical yield and percent yield were done. The final product (aspirin) percent yield was 18.247% yieldRead MoreEssay on Synthesis of Aspirin5275 Words   |  22 PagesThe Synthesis of Aspirin Chemistry Standard Level Lab Report Data Collection and Processing and Conclusion and Evaluation Date: December 8th, 2011 Purpose: The purpose of this lab was to synthesize aspirin, determine the theoretical yield, compare the percent yield to the theoretical yield and test the purity of aspirin by adding Iron (III) chloride to the product. Hypothesis: I hypothesize that salicylic acid will react with acetic anhydride to produce acetylsalicylic acid (aspirin)Read MoreSynthesis Of Aspirin Lab Report1101 Words   |  5 PagesExperiment 19: Synthesis of Aspirin and Oil of Wintergreen The purpose of this experiment was to employ techniques to synthesize aspirin and oil of wintergreen and to purify crude aspirin via recrystallization. Additionally, techniques were learned to determine the purity of the synthesized organic molecule of acetylsalicylic acid using a back-titration method. The objectives of the experiment were achieved by synthesizing the organic molecules of acetylsalicylic acid (using salicylic acid andRead MoreThe Synthesis Of Aspirin ( Acetylsalicylic Acid )2045 Words   |  9 PagesAbstract This report presents the synthesis of Aspirin (acetylsalicylic acid), as the product of the reaction of salicylic acid with ethanoic anhydride under acidic conditions. Aspirin was purified through recrystallisation by vacuum filtration, followed by desiccation of the Aspirin crystal over silica gel. The percentage yield was calculated as 44.89% and a sample of Aspirin was analysed using infra-red spectroscopy and compared to the spectrum of pure Aspirin, this served as an introduction toRead MoreSynthesis of Aspirin Lab Report2989 Words   |  12 PagesAbstract: The goal of this experiment was to synthesize aspirin. In this experiment aspirin, also known as acetylsalicylic acid, was synthesized from salicylic acid and acetic anhydride. In the reaction the hydroxyl group on the benzene ring in salicylic acid reacted with acetic anhydride to form an ester functional group. This method of forming acetylsalicylic acid is an esterification reaction. Since this esterification reaction is not spontaneous, sulfuric acid was used as a catalyst to initiateRead MoreSynthesis and Characterization of Aspirin Product Identity and Purity After synthesizing a1000 Words   |  4 PagesSynthesis and Characterization of Aspirin Product Identity and Purity After synthesizing a chemical, especially a drug, it is important to confirm the identity and purity of the product. You will perform three tests to examine the identity and purity of the aspirin that you synthesized. One test will detect the presence of leftover salicylic acid in the synthesized aspirin and allow you to determine its concentration. Government regulations stipulate that commercial aspirin must not contain residualRead MoreMicroscale Synthesis of Acetylsalicylic Acid1211 Words   |  5 PagesSynthesis of Aspirin Ling Tecson Gamido, Mitchiko Mariel M. Mizukami Abstract Acetylsalicylic acid, or also known as aspirin is known to be a drug that relives people of pain and is commonly used even today. It is synthesized from salicylic acid and ethanoic anhydride, both of small quantities. Phosphoric acid was used as a catalyst in the synthesis to speed up the process. Esterification is involved and the final product is aspirin with the presence of acetic acid as the byproduct. In orderRead MorePreparation of Aspirin and Determination of the Melting Point1445 Words   |  6 PagesPREPARATION OF ASPIRIN AND DETERMINATION OF THE MELTING POINT Ferrer, Lara Melissa V. Faculty of Engineering University of Santo Tomas Manila, Philippines ABSTRACT This experiment involved three steps: synthesis of aspirin, isolation and purification, and the estimation of purity of the final product. The synthesis involved the reaction of salicylic acid and acetic anhydride in the presence of a catalyst, phosphoric acid, H3PO4. When the aspirin was prepared, it was isolated and filtered. The percentageRead MoreThe Theory Of Green Chemistry On Microwave Heating Essay1532 Words   |  7 PagesObjective The current experiment introduces the concept of green chemistry on microwave heating to synthesise aspirin, instead of using conventional heating methods. Introduction Aspirin synthesis is a popular experiment undertaken in most organic chemistry teaching laboratories (Montes et al., 2006). Most experimental procedures for aspirin synthesis are undertaken to study the carbonyl nucleophilic substitution reactions either under basic or acidic conditions (Polshettiwar and Varma, 2008; Varma